外显子7和大部分外显子8通过同源重组被新插入的 cassette 替换, Western blot 检测证实了纯合小鼠中无蛋白表达。(来源:J:208406)
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Exon 7 and most of exon 8 were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:208406)