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中文
在E702K基因的第12号外显子中引入了一个突变，破坏了DQHA(X)2E(X)4E的金属结合motif。同时，引入了内含子12的floxed hygro/neo选择性载体。随后，通过Cre介导的重组移除了这个选择性载体。结果显示，MEFs和初级B细胞中突变等位基因的表达水平与野生型相似。在纯合小鼠的脾、脑和睾丸中， Western blot分析显示蛋白质水平大约减少了25%。(来源：J:162378)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
