构建中包含Cre重组酶,由四环素响应性调节元件(tetO)控制,以及另一个构建,其中包含rtTA,由人类ACTA1,骨骼肌α1肌动蛋白驱动元件驱动,这两个转基因元件被同时注入受精的(C57BL/6 X C3H)F2小鼠卵子中。随后建立了102号克隆。雌性祖先动物与野生型C57BL/6J雌性小鼠杂交。(来源:J:159973)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x C3H)F2
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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