将一个表型异常等位基因Ppargtm1Auww与C57Bl/6J转基因小鼠杂交,这些小鼠表达有FLP和Cre重组酶,目的是去除Frt序列下的新霉素筛选座和针对Pparg2亚型特异性的LoxP序列的exon B。通过RT-PCR确认了Pparg2亚型特异性转录本的缺失。(来源:J:161746)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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