5'UTR、exon1和exon2被替换为一个构建,包含一个由frt序列引导的neo cassette、四环素响应的(tetO/TRE)启动子、带有myc标签的Sod2基因cDNA,以及一个IRES-EGFP序列。通过胚胎纤维细胞的western blot分析,确认了没有蛋白质表达(来源:J:162190)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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