pCA-ZtTA构建设计包含了CMV增强子/鸡β-actin核心启动子(pCA)、一个由loxP标记的β-geo(lacZ-诺卡因磷酸转移酶融合)转录终止子、四环素调控的转录激活蛋白(tTA或"Tet-Off"开放阅读框,以及SV40 T-抗原的poly(A)信号。这个pCA-ZtTA构建被插入到pROSA26-PA导向载体中,生成最终的靶向载体pROSA26-ZtTA。(来源:J:161840)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
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16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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