Exon 2被替换成一个带有floxed neo cassette的元件,同时对修改后的Exon 2进行了一些核苷酸替换,导致第33位的酪氨酸(Tyr)被天冬氨酸(Cys)替换,这是一种模拟TNFR关联的周期性综合征(TNFRAPs)相关突变的改动。通过Cre介导的重组,neo cassette会被去除。(来源:J:160543)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion, Nucleotide substitutions
--
1
5
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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