Tg(LRRK2*G2019S)1Mjfa

These transgenic mice express the mutant human LRRK2 sequence, 6055G->A transition (G2019S), with high levels of protein detected in an expression pattern similar to that of the endogenous mouse Lrrk2. The transgene inserted into Chromosome 13. Transgenic mice express mutant human LRRK2 at approximately 8-10 fold over the endogenous mouse Lrrk2 level. Line 1 was generated. (J:161657)