这些转基因小鼠表达的是突变的人类LRRK2序列,6055G到A的转换(G2019S),在表达模式上类似于内源性小鼠Lrrk2,高蛋白水平检测到。转基因插入了13号染色体。转基因小鼠中的人类LRRK2表达大约是内源性小鼠水平的8-10倍。线1已经产生。(来源:J:161657)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/NTac
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插入
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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