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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(LRRK2)WT1Mjfa
Alias:
hWT
LRRK2 WT
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基础信息
表型特征
文献报道
这些转基因小鼠表达的人类LRRK2基因以高蛋白水平检测到,其表达模式类似于体内小鼠的Lrrk2。转基因插入了12号染色体。转基因小鼠中的人类LRRK2蛋白表达大约是体内小鼠Lrrk2水平的20-22倍。产生了WT1品系(来源:J:161656)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
4460657
FVB/NTac
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插入
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1
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6
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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