在第4外显子上游插入了loxP位点,然后在第7外显子下游插入了可靶向的neo cassette。通过Cre介导的重组,去除了4到7号外显子和neo cassette。蛋白表达缺失通过在尸肉脂肪滴提取物中进行 Western blot 分析得到了确认。(来源:J:160725)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd-Hprt1b-m3
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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