靶向载体包含一个在内含子2插入的诺姆-卡斯蒂莱亚(neomycin cassette),周围有loxP序列标记,以及在exon2外侧的另一个loxP位点。实验中,这些小鼠与携带Tg(EIIa-cre)的个体杂交,以去除诺姆-卡斯蒂莱亚,从而在exon2两侧留下两个loxP位点。(来源:J:160208)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
2
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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