插入了Velocigene cassette ZEN-Ub1导致17号染色体(构建GRCm39)在36,211,715-36,220,924位点间产生了一个9,210bp的缺失。lacZ和floxed neomycin抗性元件取代了所有编码外显子。逆转录-PCR证实了睾丸、肾、肝、肺、肾上腺、前列腺、脾、小肠、脂肪、胰腺、大脑和心脏中没有转录本表达。(来源:J:136110, J:201922)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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