包含起始密码子的外显子通过同源重组被新 cassette 替换。大脑提取物的 Western blot 显示无野生型蛋白存在。(来源:J:158693)
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The exon containing the start codon, was replaced with a neo cassette by homologous recombination. Western blotting of brain extracts demonstrated the absence of wild-type protein. (J:158693)