Exon 1被替换为一个包含floxed STOP cassette的载体,带有在第19位由丝氨酸替换为天冬氨酸的人源cDNA的HA标签,以及一个neo cassette。为了表达这种能抑制作用的非同源等位基因形式,需要Cre介导的重组。(来源:J:159220)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
14
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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