目标基因的开放阅读框通过同源重组在129衍生的胚胎干细胞(ES)系中被β-半乳糖苷酶(LacZ)替换。ES细胞选择中常用的PGK-neo标记位于LacZ序列下游。(来源:J:159436, J:170839)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count