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中文
目标基因的开放阅读框被替换为位于细胞核内的β-半乳糖苷酶（nLacZ，带有SV40的核定位信号），通过同源重组在129系胚胎干细胞（ES）株中实现。随后通过与表达小鼠生殖细胞Cre重组酶的背景线杂交，移除了用于ES细胞筛选的LoxP标记的neo抗性基因。(参考文献：J:159435, J:189062)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
