在上游基因区域的一个674bp神经嵴增强子区域被流式细胞仪导入的PGK-neo cassette替换。在E12.5期的同源纯合胚胎中,免疫组化显示蛋白质表达大幅减少或完全丢失。通过在Cre表达小鼠中去除PGK-neo cassette,可以实现特定组织的恢复。(来源:J:159124)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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