A 2.5 kb human podocin (NPHS2) promoter (from BAC clone RP11-231PS) was used to drive expression of cre recombinase fused to a mutated human estrogen receptor (cre/ERT2) in the transgenic construct. The cre/ERT2 cassette was followed by an SV40 polyA sequence. Three founders were generated. (J:159362)