一种含有红荧光蛋白(RFP)基因,反向接着两个loxP和frt位点标记的kanamycin和neomycin抗性基因座(loxP-pA-frt-Kan&Neo-frt-loxP)的靶向载体,被插入到内源基因的起始编码区,紧接在ATG起始密码子之后。这些带有这种突变的 mice在肾部显示出强烈的红色荧光信号,而E15.5期的杂合突变胚胎在生殖系统中也展现出与内源基因表达模式相似的荧光。(来源:J:159099)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入
不确定
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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