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在内皮1插入了floxedneo抗药性 cassette，然后在内皮2下游的exon 2前方放置了一个第三个loxP位点。之后，通过暂时的Cre表达，将选择 cassette从定向的ES细胞中去除。纯合子小鼠与Tg(EIIa-cre)C5379Lmgd小鼠杂交，以删除exon 2。对小鼠胸腺和脾细胞的蛋白质进行 Western blot分析，结果显示删除exon 2的纯合子个体中，原生蛋白和剪切形式都不表达。(来源：J:159011)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
