Exon 5中的编码第221位催化丝氨酸的区域被替换了 neo cassette,通过在肝脏提取物中进行 Western blot 分析,确实证实了没有蛋白质表达(来源:J:158743)
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Exon 5, which encodes the catalytic serine at position 221, was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:158743)