在翻译起始位点下游插入了带有SV40 3' UTR和一个floxed neo cassette的荧光素酶编码序列,它取代了前4个编码外显子。通过Cre介导的重组,neo cassette被去除了。蛋白表达的缺失通过胚胎纤维细胞提取物的Western blot分析得到了确认。(来源:J:158934)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入
--
1
--
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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