通过Cre介导的重组,移除了MICER克隆中3到8号外显子,这些外显子带有K14-Agouti基因、3'的Hprt、LoxP位点以及下游插入的puro cassette,1和2号重复序列以及8号外显子后插入的neo cassette、LoxP位点、5'的Hprt和酪氨酸酶基因。转录表达的缺失通过在海马和皮质提取物中进行RT-PCR分析得到了确认。(来源:J:158715)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入,基因内删除
--
1
4
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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