这个转基因表达的是人类TSHRα亚基的cDNA(1-289氨基酸残基),带有6个His标签,由牛甲状腺球蛋白启动子控制。通过RT-PCR分析,发现转基因小鼠甲状腺组织中检测到了人类TSHRα亚基的表达。另外,生成了线路51.9和60.6(来源:J:118100)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(BALB/c x C57BL/6)F1
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1
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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