Tg(Thy1-APPDutch)#Jckr

A human APP751 cDNA with a mutation in the codon for amino acid residue 693 causing a glutamic acid to glutamine change (E693Q) was place under the control of the murine Thy1.2 minigene. Five positive founder mice were identified. This record is for combined data from the two highest expressing lines, lines 23 and 33. Expression is five times higher than for endogenous APP. (J:92796)