设计了一种靶向载体,它包含Dikkopf-Like 1(Dkkl1)基因的2-4号外显子两侧的loxP位点,以及3'端loxP位点上游的Frt-flanked诺卡因抗性(neo)基因座。通过Cre介导的重组,去除了2-4号外显子和Frt-flanked neo基因座,通过免疫组化在睾丸样本中证实了蛋白表达的缺失。(来源:J:158272)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count