设计了一种靶向载体,它包含Dikkopf-Like 1(Dkkl1)基因的2-4号外显子两侧的loxP位点,以及3'端loxP位点上游的Frt-flanked诺卡因抗性(neo)基因座。通过Cre介导的重组,去除了2-4号外显子和Frt-flanked neo基因座,通过免疫组化在睾丸样本中证实了蛋白表达的缺失。(来源:J:158272)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部