Tie2特异性内皮驱动的 Tie2(tek)启动子/增强子驱动小鼠Par1(f2r)基因的表达。构建包含tek内皮特异性启动子(带有f2r cDNA)和SV40polyA序列,后面跟着tek的内皮特异性增强子。通过RT-PCR,在E8.0时能在内皮和心内膜中检测到转基因f2r的特异性表达。产生了两个独立的杂交瘤品系,当与F2rtm1.1Cgh背景杂交时,结果相似。选择Line 1来标识这一品系,引用文献为(J:71309)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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