在启动子的8个碱基上游插入了GFP基因座,而在exon 2的下游110个碱基位置反向插入了neo基因,导致exon 2的编码区域和部分内含子2被替换。RT-PCR在纯合小鼠中未检测到转录本,但GFP蛋白表达可见。(来源:J:157256)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv
Targeted
插入,基因内删除
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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