Exon 1和2被删除,并用一个含荧光尼卡因 cassette 替换。选择 cassette 通过 Cre介导的重组移除。RNA和蛋白质缺失通过northern和western blotting进行了确认。表达缺失并未改变与之绑定伙伴NFATC1、NFATC2和NFATC3(J:157559)的稳定性。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count