Exon 1和2被删除,并用一个含荧光尼卡因 cassette 替换。选择 cassette 通过 Cre介导的重组移除。RNA和蛋白质缺失通过northern和western blotting进行了确认。表达缺失并未改变与之绑定伙伴NFATC1、NFATC2和NFATC3(J:157559)的稳定性。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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