Ret基因的第一个外显子被靶向用于同源重组。一个编码可诱导的Cre/ERT2的序列,后面跟着一个由loxP序列标记的AC-Cre Tn5-neo自剪切 cassette,被定向插入Ret基因的第1外显子中。在剪除含floxed neo的 cassette后,产生了表达Cre/ERT2的敲入小鼠品系。这种可诱导Cre的时空表达模式再现了Ret基因的表达模式。(来源:J:157722)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
23
35

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部