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中文
THpPLAP转基因是通过将人胎盘碱性磷酸酶(ALPP或hPLAP)基因，由鼠的酪氨酸羟化酶(TH)启动子驱动，插入猴病毒40(SV40)的间隔序列和SV40的polyadenylation位点设计而成。这个转基因品系包含了50个拷贝的基因。PLAP能在表达DA释放的、具有儿茶酚胺能的视网膜视锥细胞和大脑多巴胺神经元，包括黑质、伏隔核和嗅球的细胞膜外表面强烈标记。此外，它对蓝斑的去甲肾上腺素神经元(norepinephrine)标记较弱，对视网膜的第二型儿茶酚胺能视锥细胞(信号未知)的标记则很轻微。(来源：J:157684)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
