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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Gt(ROSA)26Sor
tm1(RARA*)Clmd
Alias:
Gt(ROSA)RARa403
RaraDN
flox
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基础信息
表型特征
文献报道
一段被截短的人类RARA基因,从第403位氨基酸后终止,被定向插入到Rosa26染色体上,但直到通过Cre介导的重组移除一个loxP末端的终止序列后才开始表达。(来源:J:157254)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
4431227
129/SvEv
Targeted
插入
--
--
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14
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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