在exon 4的上游插入了loxP位点,然后在exon 6的下游插入了一个带有3' loxP座的frt标记neo cassette。通过Flp酶介导的重组,neo cassette被移除,导致exon 4到6区域被标记为可剪接。(来源:J:157318)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count