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中文
一个新霉素抗性基因座替换了编码尾部序列的第九外显子。剪接增加了从第八外显子序列后跟的23个额外氨基酸。通过测序确认了第九外显子的缺失。在体内，通过Cre介导的重组，删除了携带新霉素抗性标记的序列。脑组织的提取物进行 Western blot 分析显示，总蛋白表达水平与野生型小鼠相似。ELISA检测显示血浆中可溶性蛋白水平降低了两倍。(来源：J:157170)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
