在exon 2的第25位,Leucine的密码子(TTA)被替换为Glutamine(谷氨酰胺),而Tryptophan的密码子26(TTG)被替换为Serine(丝氨酸)(p.L25Q, p.W26S)。接着,一个由LoxP序列标记的诺卡因抗性基因座被插入到intron 4。之后,通过Cre介导的重组,这个诺卡因基因座被去除了。(来源:J:157299)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
Insertion, Nucleotide substitutions
--
1
65
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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