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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Trp53
tm6Xu
Alias:
p53
Gln25Ser26
p53
QS-Neo
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基础信息
表型特征
文献报道
在exon 2的第25位,Leucine的密码子(TTA)被替换为Glutamine(谷氨酰胺),而Tryptophan的密码子26(TTG)被替换为Serine(丝氨酸)(p.L25Q, p.W26S)。接着,一个由LoxP序列标记的诺卡因抗性基因座被插入到intron 4。之后,通过Cre介导的重组,这个诺卡因基因座被去除了。(来源:J:157299)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
4430743
129S4/SvJae
Targeted
Insertion, Nucleotide substitutions
--
1
65
2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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