一个1.6kb编码cre重组酶的片段,后面跟着兔β-球蛋白的polyadenylation信号,被用来构建一个靶向载体。通过同源重组,这个载体将Foxl2的起始翻译位点替换为cre-ATG的起始密码子。靶向载体包含一个自我剔除的neo cassette(ACN cassette)和一个无溶血性链球菌毒素的筛选 cassette(DTA)。ACN cassette在通过雄性生殖系统时会被剔除。(来源:J:157008)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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