在exon 11引入了带有5个氨基酸替换(lysine替换为甘氨酸)的突变NLS1,通过同源重组在intron 10插入了一个floxed neo cassette。 Western blot结果显示,全长突变蛋白的检测水平极低,而包含N端半部分的片段则有较低水平。(来源:J:156743)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
Insertion, Nucleotide substitutions
--
1
9
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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