在 intron 3 内插入了一个带有floxed neo cassette,通过同源重组在exon 3引入了特定的核苷酸突变。这种突变导致JNK蛋白激酶的磷酸化位点(Ser-74)被Asp(S74D)替换。随后,neo cassette通过Cre介导的重组被剔除,留下一个在intron 3中的单个loxP位点。(来源:J:153652)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Nucleotide substitutions
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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