The transgene construct contains the rat nestin second intron enhancer fused to an hsp68 (Hspa1b) minimal promoter driving a 1.6 kb cre sequence fused to the tamoxifen-inducible mutant estrogen receptor (Esr1*). The linearized construct was microinjected into pronuclei of fertilized C57BL/6 eggs. Three lines of nestin-cre/Esr1* mice were generated. (J:156372)