将creERT2表达座由包含内含子2的兔β-球蛋白DNA(β-球蛋白间隔序列[bGIVS])开头,以SV40polyA信号和由FRT位点 flank 的PGK/Tn5驱动的诺卡因抗性座(neo)结尾,通过同源重组插入了Aqp4基因的启动子位点,该基因位于BAC RP23-189N2中。将线性载体注入了FVB/N卵母细胞的核中。在第55-27行,检测到了cre/ERT2 mRNA,它在大脑相似区域有,但浓度显著较低。(来源:J:156087)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
IF
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