在Aggrecan基因的3' UTR位置,通过同源重组的方式插入了IRES-cre/ERT2和一个反向排列的FRT-flanked PGK-neo选择座。这个操作在G4 ES细胞中完成,随后通过与C57BL/6小鼠的杂交建立了这个转基因品系。neo座标记并未剔除。(来源:J:155982)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入
--
1
5
59

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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