在第23外显子被标记为floxed后,通过同源重组在第23内含子插入了带有FRT座标的neo cassette。随后,通过flp和cre介导的重组分别去除了选择 cassette 和第23外显子。cre介导的重组导致了错位剪接和突变转录本的无义介导降解。(来源:J:155739)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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