Tg(CAG-SPTLC1*C133W)8EAmcc

The CAG promoter drives ubiquitous expression of the hamster cDNA containing nucleotide substitutions that result in the amino acid substitution of tryptophan for cysteine at position 133 (C133W). This mutation is commonly found in patients with type 1 hereditary sensory and autonomic neuropathy (HSAN1). Three lines were created (lines 8B, 8E, and 8F) with lines 8E expressing the highest levels and selected as the representative line. (J:106812)