在exon 11的第330位,一个谷氨酸被点突变成了谷氨酰胺,这是通过一种基因突变实现的。靶向载体包含一个由cre介导的重组系统去除的loxP位点的诺卡因 cassette。细胞活性检测证实了纯合小鼠细胞中ADAM8酶活性的缺失。(来源:J:155243)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
DBA/1LacJ
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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