在exon 7中产生了一个突变,导致第629位的精氨酸被天冬氨酸替换(N629D)。同时,一个由floxed polII驱动的诺卡因筛选 cassette被插入到了intron 7。为了去除诺卡因选择性标记,这些小鼠与Meox2小鼠进行了杂交。(来源:J:155273)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count