HSAnatLSP-IL15转基因是通过修改的人类骨骼肌Actin(HSA或ACTA1)启动子片段(-2139至+239),小鼠长信号肽(LSP)的IL-15(Il15)cDNA,以及polyA信号构建的。这个转基因在C57BL/6xC3H杂交胚胎的卵母细胞核中进行了微注射。后代个体被鉴定出来,并与C57BL/6J小鼠杂交,建立了10941品系(稳定单一的转基因插入点)。在去势雄性和雌性中,IL-15的mRNA/蛋白质表达分别大约是纯合体的300倍和400倍,以及100倍和400倍。(来源:J:145611)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6 x C3H
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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