插入了Velocigene cassette ZEN-Ub1导致染色体17(GRCm39构建)在28,361,503-28,390,339位点间形成了一个28,837bp的缺失。该缺失位置的基因表达被报告基因复制,类似于内源基因的表达模式。 Western blot实验确认了纯合胚胎中没有蛋白质表达。(来源:J:136110, J:195784)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
1
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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