插入了Velocigene cassette ZEN-Ub1导致1033bp的缺失,位置在18号染色体(构建GRCm39)的32,080,26-32,081,058区间。Gpr17基因位于Lims2的反向链中,其单一编码外显子完全被Lims2的长内含子4包含。lacZ和floxed neomycin选择座在Gpr17的起始密码子(ATG)之后整合,没有删除Lims2的任何外显子。在纯合突变小鼠的下丘脑中未检测到Gpr17的mRNA。(参考文献:J:136110, J:219560)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
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1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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