在exon 2上游插入了一个5'有loxP位点的弗里披(FRT)引导的neo cassette,同时在exon 2下游也增加了另一个loxP位点。通过Flp介导的重组,neo cassette被移除,exon 2区域被标记为可剪接。(来源:J:155630)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count