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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Cyp3a
tm1.1Arte
Alias:
Cyp3a
-
/3a13
+
Del(5Cyp3a57-Cyp3a59)1Arte
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基础信息
表型特征
文献报道
Cyp3a57的exons1和2被替换成含loxP位点的hygromycin cassette,随后在Cyp3a59的内含子4中插入了另一个含loxP位点的neomycin cassette。通过Cre介导的重组酶,Cyp3a57、Cyp3a16、Cyp3a41、Cyp3a44、Cyp3a11、Cyp3a25以及Cyp3a59的1到4号外显子和启动子被删除了。(来源:J:147112)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
4414654
C57BL/6NTac
Targeted
Insertion, Intergenic deletion
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7
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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