Cyp3a57的exons1和2被替换成含loxP位点的hygromycin cassette,随后在Cyp3a59的内含子4中插入了另一个含loxP位点的neomycin cassette。通过Cre介导的重组酶,Cyp3a57、Cyp3a16、Cyp3a41、Cyp3a44、Cyp3a11、Cyp3a25以及Cyp3a59的1到4号外显子和启动子被删除了。(来源:J:147112)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6NTac
Targeted
Insertion, Intergenic deletion
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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